Safe in Pregnancy – Up-to-date evidence-based information on vaccines in pregnancy

The Continuous Textbook of Women’s Medicine Series – Maternal immunization

Professor Asma Khalil - The Royal College of Obstetricians and Gynaecologists, London, UK University College London Hospitals NHS Foundation Trust, London, UK
Professor Flor M Munoz - Baylor College of Medicine, TX, USA Professor Ajoke Sobanjo-ter Meulen - University of Washington, Seattle, WA, USA

Safety, immunogenicity, and effectiveness of COVID-19 vaccines for pregnant persons: A protocol for systematic review and meta analysis

We aim to conduct a living systematic review and meta-analysis based on biweekly searches of medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries to systematically identify relevant studies of COVID-19 vaccines for pregnant persons.

Data collection systems for active safety surveillance of vaccines during pregnancy in low- and middle-income countries: developing and piloting an assessment tool (VPASS)

We conducted a rapid review of the literature to identify frameworks on population health or post-marketing drug surveillance. Four frameworks that met the eligibility criteria were identified and served to develop an assessment tool capable of evaluating sites that could support active monitoring of vaccine safety during pregnancy.

Safety of COVID-19 vaccines during pregnancy: A systematic review and meta-analysis

A systematic review and meta-analysis to evaluate the safety of COVID-19 vaccines, including their components and technological platforms used in other vaccines during pregnancy and animal studies to complement direct evidence.

Safety of components and platforms of COVID-19 vaccines considered for use in pregnancy: A rapid review

A rapid systematic review to evaluate the safety of COVID-19 vaccines selected by the COVID-19 Vaccines Global Access-Maternal Immunization Working Group in August 2020.

Using maternal and neonatal data collection systems for coronavirus disease 2019 (COVID-19) vaccines active safety surveillance in low- and middle-income countries: an international modified Delphi study

Excluding pregnant women from studies on vaccination in order to provide protection from theoretical risks is not warranted and can prevent this population from potentially beneficial inmunizations.

COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes

We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal and child health following Cochrane methods and PRISMA statement for reporting.

Maternal and neonatal data collection systems in low- and middle-income countries for maternal vaccines active safety surveillance systems: A scoping review

Our study’s main objective was to identify existing perinatal data collection systems in low- and middle-income countries that collect individual information on maternal and neonatal health outcomes and could be developed to inform active safety surveillance of novel vaccines for use during pregnancy.

Advisory Board Technical Consultation for COVAX Maternal Immunization Work Group: Maternal Immunization Post-Licensure Safety Needs for Pregnant Women and their Infants

The COVAX Maternal Immunization Work Group (WG) was established with the goal of developing a report that identifies and provides recommendations on COVID-19 candidate vaccine(s) for potential use in pregnant women.

Maternal and neonatal data collection systems in low- and middle-income countries: scoping review protocol

A recent analysis reported that most vaccine pharmacovigilance systems in low- and middle-income countries consist of spontaneous (passive) adverse event reporting. Thus, LMICs need effective active surveillance approaches, such as pregnancy registries.

Up-to-date evidence-based information on vaccines in pregnancy

Living Systematic Review

Maternal Pregnancy Outcomes

Maternal Adverse Events Following Immunization

Infant Safety Outcomes

Vaccine Efficacy / Effectiveness Outcomes

Resources